For the Millions of People Who Suffer From Chronic Venous Disease

The Only Highly Purified Formulation of Diosmin Available in The U.S. that Manages the Inflammation Associated with Chronic Venous Disease (CVD)

Chronic Venous Disease (CVD) is a chronic, progressive disease of the veins that can lead to a variety of health issues such as leg edema (fluid retention), varicose veins, leg ulcers, stasis dermatitis (skin disease leading to ulcers), hemorrhoids.

Vasculera is a prescription medical food containing highly-purified diosmin, a flavonoid isolated from hesperidin found in citrus that restores the body’s microcirculatory balance. You would need to eat approximately 140 oranges a day (rind included) to consume the equivalent amount of diosmin packed into a single, easy-to-swallow Vasculera tablet.

Diosmin, the primary ingredient in Vasculera, has been used globally for more than 30 years and recommended in clinical-practice guidelines, supported by a body of evidence and world-renowned vascular experts. More than 50 published and peer-reviewed clinical studies show that diosmin is effective and safe in managing CVD. Vasculera has earned the highest standard of safety at the FDA: the ingredients have been designated “Generally Recognized as Safe” (GRAS).

Vasculera’s proprietary formula combines disosmin with alka-4 complex (diosmiplex). Alka-4 complex counters venous acidosis (acidity in the blood), which can cause further destruction of the veins.

Vasculera is dispensed by prescription and is to be used under a physician's supervision.

“I cannot say enough about Vasculera... all the symptoms I was experiencing disappeared. I really could not believe it.”

- Lee

“My legs were very large and made it hard to find pants to fit me, not to mention the constant aches. After about 2 weeks, I started noticing that my pants were fitting better, and my legs did not ache.”

- Duane

Manages All 8 Aspects of CVD

More than three decades of published clinical studies worldwide have shown that the diosmin in Vasculera manages ulcers and has an impact on all 8 manifestations of CVD:









Patient Resources

Have questions about Vasculera? Contact one of our dedicated Patient Advocates at 1-888-546-2765 weekdays from 8:30 a.m. - 5:30 p.m. Arizona time.

Frequently Asked Questions

Veins bring blood back to the heart. Small valves in the vein make sure blood flows in one direction, but when they are damaged, blood flow decreases and can “pool” in the veins. When blood pools, it absorbs acidic metabolic waste products and makes the problem worse. Damaged veins that work improperly for long periods of time can cause CVD.

Blood clots, obesity, smoking, muscle weakness, leg injury, and other risk factors can cause vein damage. Sitting or standing for a long time without moving can also cause problems in the leg veins. Symptoms of CVD include heavy legs, aching, swelling, discoloration of the skin and chronic hemorrhoids. Severe cases of CVD can lead to ulcers and deep vein thrombosis.

Vasculera is a prescription medical food for the dietary management of CVD. It is made from flavonoids with powerful antioxidant and anti-inflammatory benefits. Vasculera brings back the natural balance of microcirculatory processes associated with CVD and its symptoms, including venous hypertension, venous acidosis (acidity in the blood) and inflammation.

Vasculera is a prescription medical food. The U.S. Food and Drug Administration (FDA) regulates medical foods in a separate category than drugs and supplements. Similar to drugs, medical foods help manage diseases and require physician supervision. Sound laboratory and clinical science must prove the effectiveness of a medical food. Dietary supplements are meant for healthy people and do not require a prescription. The term “food” speaks to the safety of these products because they must contain only ingredients that have been designated as GRAS (Generally Recognized as Safe), a strict food-safety standard set by the FDA.

Vasculera is a 630mg diosmiplex tablet. Diosmiplex is a combination of purified diosmin (600mg) and alka4-complex (30mg).

Diosmin is a MPFF (micronized purified flavonoid fraction) derived from hesperidin found in oranges and other citrus fruit, with the highest concentration in the rinds (see the USDA flavonoid database). Flavonoids are healthy ingredients that give color to vegetables, fruits, cocoa, red wine and green tea. To get the same amount of diosmin packed into a single Vasculera tablet, you would need to eat about 140 oranges per day (rind included). Diosmin has been used in Europe as a prescription product for more than 30 years. Dozens of well-documented clinical studies support its effectiveness and safety.

Alka4-complex is an antacid. It works against acidity in the blood, which damages veins. Vasculera does not contain fructose, glucose, sucrose, lactose, gluten, maltodextrin, tree nuts, peanuts, or flavors and is suitable for vegans.

Commonly reported side effects of diosmin include gastrointestinal disturbances and headaches. These side effects were generally mild, and patients didn’t stop using the product. No serious adverse events have been reported in any study of products similar to Vasculera. Please see the Vasculera package insert for more information.

More than 50 published and peer-reviewed clinical studies show the effectiveness and safety of diosmin to manage CVD. Diosmin, the primary ingredient in Vasculera, has more than three decades of demonstrated clinical results worldwide. It is commonly used in other parts of the world and is now available in the U.S.

For managing CVD, take one tablet of Vasculera (diosmiplex 630 mg) per day. For hemorrhoid flares, the recommendation is to begin with one tablet three times a day for four days. Then, take one tablet twice daily for nine days, or as directed by a physician. To manage chronic hemorrhoidal disease, take one tablet daily. If indigestion occurs, take Vasculera with food.

If you forget to take Vasculera, resume your normal number of tablets on your regular schedule as prescribed.

Some patients experience an effect on leg tingling, discomfort, heaviness or edema within one week. Depending on the severity of the disease, some patients do not see differences in skin or vein appearance for four to eight weeks. For venous ulcers, patients may see results after several months. For hemorrhoids, patients may see results within days.

Vasculera is not for patients with hypersensitivity to any of its ingredients. Vasculera is not recommended for pregnant or lactating women. Drug interactions have been described with chlorzoxazone (Parafon Forte), diclofenac (Voltaren) and metronidazole (Flagyl). These reports were based on pharmacokinetic studies in healthy people, but have not been reported in clinical practice. If you believe you are having a drug interaction, tell your doctor right away.

Pay no more than $49 on every Vasculera prescription*

At Primus Pharmaceuticals, we help patients get the best price on Vasculera. Primus Care Direct is our hassle-free prescription mail-order program. Filling your Vasculera prescription with Primus Care Direct is quick and easy.

Here is how it works:

  1. Your healthcare practitioner will send your prescription to Primus Care Direct.
  2. Primus Care Direct will collect your insurance, billing and shipping information.
  3. You are guaranteed to receive the lowest possible price on Vasculera (Medicare patients included).
  4. Your prescription will be shipped free to your home.

If you have any questions about Primus Care Direct or Vasculera, contact one of our dedicated Patient Advocates at 1-888-546-2735 weekdays from 8:30 a.m. - 5:30 p.m. Arizona time.

*Offer based on 30-day supply at prescribed one tablet per day dose.

Advocating for Better Access to Vasculera

Without affordable access to Vasculera, and other prescription medical foods, patients will suffer. This is why Primus Pharmaceuticals (makers of Vasculera) started an advocacy movement to help patients, families, caregivers, healthcare providers and others have a voice to take control of their health with better access to safer medicines.

Increasingly, Medicare, Medicaid, Tricare and commercial health plans will only cover expensive synthetic drugs that merely treat symptoms and can cause serious adverse events.

Due to their safety profile and lack of drug-on-drug interaction, medical foods are often prescribed for chronic conditions in patient populations that have other diseases increasing their health risks from side effects associated with traditional drugs. Without easy access to prescription medical foods, patients in these special co-morbid populations will continue to suffer.